Cefoperazone Sodium/Sulbactam Sodium 1:1

  1. CAS No.:62893-20-3 (Cefoperazone sodium); 69388-84-7 (Sulbactam Sodium)
  2. Chemical formula:  C25H26N9NaO8S2 (Cefoperazone Sodium); C8H10NNaO5S (Sulbactam Sodium)
  3. Molecular weight:

    667.65 (Cefoperazone Sodium);                            255.22 (Sulbactam Sodium)

Detailed Description

Cefoperazone Sodium/Sulbactam Sodium (1:1) (Syn: Sulperazon) is a sterile homogeneous mixture of two parts Cefoperazone Sodium and one part Sulbactam Sodium by weight. It was developed in response to the β-lactamase challenge, due to the apperance of organisms resistant to β-lactam antibiotics. Cefoperazone is a β-lactam antibiotic, and Sulbactam is a β-lactamase inhibitor, which helps prevent bacteria from hydrolyzing the cefoperazone and thus restore the usefulness of the compound. This product is frequently used against the bacteria causing respiratory and urinary tract infections.

Mechanism of Action

Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases.

Storage conditions